Synthesis of Diversified Pyrazolo[3,4-b]pyridine Frameworks from 5-Aminopyrazoles and Alkynyl Aldehydes via Switchable C≡C Bond Activation Approaches

Autor:	Xiao-Yu Miao, Yong-Ji Hu, Fu-Rao Liu, Yuan-Yuan Sun, Die Sun, An-Xin Wu, Yan-Ping Zhu
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	pyrazolo[3 4-b]pyridine alkyne activation regional selectivity 6-endo-dig cyclization Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 19, p 6381 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27196381
Popis:	A cascade 6-endo-dig cyclization reaction was developed for the switchable synthesis of halogen and non-halogen-functionalized pyrazolo[3,4-b]pyridines from 5-aminopyrazoles and alkynyl aldehydes via C≡C bond activation with silver, iodine, or NBS. In addition to its wide substrate scope, the reaction showed good functional group tolerance as well as excellent regional selectivity. This new protocol manipulated three natural products, and the arylation, alkynylation, alkenylation, and selenization of iodine-functionalized products. These reactions demonstrated the potential applications of this new method.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/59a762a8d88b41e3833b0fbb1e0590f1 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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