| Autor: |
A.A. Khabarova, I.E. Pristyazhnyuk, P.A. Orlova, T.V. Nikitina, A.A. Kashevarova, M.E. Lopatkina, E.O. Belyaeva, N.N. Sukhanova, L.P. Nazarenko, I.N. Lebedev, O.L. Serov |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Stem Cell Research, Vol 49, Iss , Pp 102076- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1873-5061 |
| DOI: |
10.1016/j.scr.2020.102076 |
| Popis: |
Ring chromosome 18 is a rare chromosomal disorders that usually originate de novo and correlate with clinical manifestation: developmental delay as well as microcephaly, brain and ocular malformations, hypotonia and skeletal abnormalities. We generate iPSC clonal cell line ICGi024-A with pluripotency properties which were demonstrated in vitro by three germ layer differentiation capacity. ICGi024-A can be used for disease modeling and fundamental investigation of ring chromosome instability. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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