Study of the pharmacokinetics of antituberculosis drug Biomairin
| Autor: | Sh. A. Shomurotov, E. M. Sultanova, M. K. Salakhutdinova, U. J. Ishimov, J. F. Ziyavitdinov, O. N. Veshkurova, A. S. Turaev |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 50-55 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2587-7836 2686-8830 |
| DOI: | 10.24411/2587-7836-2018-10030 |
| Popis: | Resume. The results of a studying the pharmacokinetics of the anti-tuberculosis drug Biomayrin in experimental animals (rats) after oral administration were presented. A comparative analysis of the pharmacokinetic parameters of Biomayrin with a comparing drug (a mixture of rifampicin, ethambutol and isoniazid) showed that the bioavailability of isoniazid increased four times as a part of Biomayrin, the ethambutol and rifampicin three times compared to the comparing drug, thereby showing a prolonged effect. It should also be noted that the introduction of isoniazid into the polysaccharide matrix retards its metabolism to the therapeutically inactive acetylisoniazid. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|