| Autor: |
Marta Przymuszała, Alicja Martyniak, Joanna Kwiatkowska, Jarosław Meyer-Szary, Karolina Śledzińska, Jolanta Wierzba, Józef Dulak, Urszula Florczyk-Soluch, Jacek Stępniewski |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Stem Cell Research, Vol 76, Iss , Pp 103327- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1873-5061 |
| DOI: |
10.1016/j.scr.2024.103327 |
| Popis: |
Becker muscular dystrophy (BMD) is an X-linked recessive disorder caused by in-frame deletions in the dystrophin gene (DMD), leading to progressive muscle degeneration and weakness. We generated a human induced pluripotent stem cell (hiPSC) line from a BMD patient. BMD hiPSCs were then engineered by CRISPR/Cas9-mediated knock-in of missing exons 3–9 of DMD gene. Obtained hiPSC line may be a valuable tool for investigating the mechanisms underlying BMD pathogenesis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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