Fludarabine Treatment of Patient with Chronic Lymphocytic Leukemia Induces a Digital Ischemia

Autor:	Utku Erdem Soyaltin, Deniz Yuce Yildirim, Mustafa Yildirim, Mehmet Can Ugur, Ferhat Ekinci, Cengiz Ceylan, Harun Akar
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Case Reports in Hematology, Vol 2016 (2016)
Druh dokumentu:	article
ISSN:	2090-6560 2090-6579
DOI:	10.1155/2016/7362791
Popis:	We report a 63-year-old man with a history of chronic lymphocytic leukemia (CLL) who presented with asymmetrical Raynaud’s phenomenon of sudden onset which progressed to acral gangrene rapidly in a week. These symptoms began approximately one week after the fourth cycle of fludarabine and cyclophosphamide chemotherapy and were accompanied by pain, numbness, and cyanosis in the fingers of his right hand except the first finger. Fludarabine may play a role in acral vascular syndrome. The treatment with fludarabine in patients with evolving digital ischemia should be carried out with caution.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c5986822706940ecb0bd7a71d59c56d3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF