White matter microstructural alterations in patients with neuropathic pain after spinal cord injury: a diffusion tensor imaging study

Autor: Dong Dong, Koichi Hosomi, Nobuhiko Mori, Yoshi-ichiro Kamijo, Yohei Furotani, Daisuke Yamagami, Yu-ichiro Ohnishi, Yoshiyuki Watanabe, Takeshi Nakamura, Fumihiro Tajima, Haruhiko Kishima, Youichi Saitoh
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Neurology, Vol 14 (2023)
Druh dokumentu: article
ISSN: 1664-2295
DOI: 10.3389/fneur.2023.1241658
Popis: BackgroundThrough contrastive analysis, we aimed to identify the white matter brain regions that show microstructural changes in patients with neuropathic pain (NP) after spinal cord injury (SCI).MethodsWe categorized patients with SCI into NP (n = 30) and non-NP (n = 15) groups. We extracted diffusion tensor maps of fractional anisotropy (FA) and mean (MD), axial (AD), and radial (RD) diffusivity. A randomization-based method in tract-based spatial statistics was used to perform voxel-wise group comparisons among the FA, MD, AD, and RD for nonparametric permutation tests.ResultsAtlas-based analysis located significantly different regions (p
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