| Autor: |
Zeyan Ye, Dechan Tan, Tingyu Luo, Ruoyu Gou, Jianshen Cai, Yanfei Wei, Kailian He, Song Xiao, Tingyu Mai, Xu Tang, Qiumei Liu, Xiaoting Mo, Yinxia Lin, Shenxiang Huang, You Li, Jian Qin, Zhiyong Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-11 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1755-8794 |
| DOI: |
10.1186/s12920-023-01632-6 |
| Popis: |
Abstract Objective To analyze the relationship between plasma metal elements, ApoE gene polymorphisms and the interaction between the two and impaired cognitive function in elderly population. Method A stratified sample was drawn according to the age of the study population, and 911 subjects were included. Baseline information and health indicators were obtained, and cognitive function status was assessed by health examination, a general questionnaire and Mini-Mental Status Examination. Plasma metal elements were measured, and SNP typing was performed. Binary logistic regression was used to analyze the factors influencing cognitive function status and the association between the SNP genetic pattern of the ApoE gene and cognitive function. Results The differences in gene frequencies and genotype frequencies of the ApoE rs7412 and rs7259620 genotype frequencies were statistically different between the cognitive impairment group and the control group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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