| Autor: |
J.C. López-Alvarenga, S. Sobrino-Cossío, J.M. Remes-Troche, J. Chiu-Ugalde, J.A. Vargas-Romero, M. Schmulson |
| Jazyk: |
Spanish; Castilian |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Revista de Gastroenterología de México, Vol 78, Iss 1, Pp 21-27 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
0375-0906 |
| DOI: |
10.1016/j.rgmx.2012.10.003 |
| Popis: |
Background: Irritable Bowel Syndrome (IBS) is a disorder characterized by abdominal pain or discomfort associated with changes in bowel habit. Currently there are no objective outcome measures for evaluating the effectiveness of treatments for this disorder. Aims: To determine the usefulness of a method of analysis that employs polar vectors to evaluate the effectiveness of IBS treatments. Methods: Data from a Phase IV clinical study with 1677 active IBS-Rome III patients who received 100 mg of pinaverium bromide + 300 mg of simethicone (PB + S) po bid for a period of four weeks were used for the analysis. Using the Bristol Stool Scale as a reference, the consistency and frequency of each type of bowel movement were recorded weekly in a Bristol Matrix (BM) and the data were expressed as polar vectors. Results: The analysis showed a differential response to the PB + S treatment among the IBS subtypes: in reference to the IBS with constipation subtype, the magnitude of the vector increased from 10.2 to 12.5, reaching maximum improvement at two weeks of treatment (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
