Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer

Autor:	Erin M. Dickey, Anna Bianchi, Haleh Amirian, Peter J. Hosein, Denise Faustman, Roberta Brambilla, Jashodeep Datta
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Chemotherapy immunotherapy myeloid-derived suppressor cells neutrophils pancreatic cancer TNFR2 Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 13, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	2162402X 2162-402X
DOI:	10.1080/2162402X.2024.2326694
Popis:	Pancreatic cancer is characterized by extreme therapeutic resistance. In pancreatic cancers harboring high-risk genomes, we describe that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane (tm)TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T-cell dysfunction – two hallmarks of therapeutic resistance. Targeting tmTNF-TNFR2 signaling may sensitize pancreatic cancer to chemo±immunotherapy.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/594a145cfa4a4bf9ba5e867138b3d07d Zobrazit plný text záznamu View record in DOAJ