Triterpenic Acid Amides as a Promising Agent for Treatment of Metabolic Syndrome

Autor:	Vladislav Fomenko, Mikhail Blokhin, Sergey Kuranov, Mikhail Khvostov, Dmitriy Baev, Marina S. Borisova, Olga Luzina, Tatyana G. Tolstikova, Nariman F. Salakhutdinov
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	type 2 diabetes mellitus hypoglycemic activity natural product triterpenic amides glucose tolerance total cholesterol Pharmacy and materia medica RS1-441
Zdroj:	Scientia Pharmaceutica, Vol 89, Iss 1, p 4 (2020)
Druh dokumentu:	article
ISSN:	2218-0532 0036-8709
DOI:	10.3390/scipharm89010004
Popis:	A series of triterpenic acid amides were synthesized incorporating a 2-ethoxy-3-phenylpropanoic acid pharmacophore fragment. The synthesized compounds were tested for their ability to improve glycemic control and to counter lipid abnormalities in C57BL/6 mice placed on a high-fat/high-cholesterol diet. Of all tested compounds, the dihydrobetulonic derivative (16b) had the most pronounced effect in decreasing blood glucose levels, total cholesterol (TC), and high-density lipoproteins (HDL). All the synthesized compounds displayed a relatively safe profile in the animal studies carried out in this work.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/59471e1f87c84364a3bbdfdfd1b3166b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF