Genetic basis of job attainment characteristics and the genetic sharing with other SES indices and well-being

Autor: Zhaoli Song, Wen-Dong Li, Hengtong Li, Xin Zhang, Nan Wang, Qiao Fan
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-12905-y
Popis: Abstract Job attainment is an important component of socioeconomic status (SES). There is currently a paucity of genomic research on an individual’s job attainment, as well as how it is related to other SES variables and overall well-being at the whole genome level. By incorporating O*NET occupational information into the UK Biobank database, we performed GWAS analyses of six major job attainment characteristics—job complexity, autonomy, innovation, information demands, emotional demands, and physical demands—on 219,483 individuals of European ancestry. The job attainment characteristics had moderate to high pairwise genetic correlations, manifested by three latent factors: cognitive, emotional, and physical requirements. The latent factor of overall job requirement underlying the job attainment traits represented a critical genetic path from educational attainment to income (P
Databáze: Directory of Open Access Journals
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