Synthetic, Structural, and Anticancer Activity Evaluation Studies on Novel Pyrazolylnucleosides

Autor:	Yogesh Yadav, Deepti Sharma, Kumar Kaushik, Vineet Kumar, Amitabh Jha, Ashok K. Prasad, Christophe Len, Sanjay V. Malhotra, Jesper Wengel, Virinder S. Parmar
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	pyrazolylnucleosides modified nucleosides noesy study anticancer nci-60 Organic chemistry QD241-441
Zdroj:	Molecules, Vol 24, Iss 21, p 3922 (2019)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules24213922
Popis:	The synthesis of novel pyrazolylnucleosides 3a−e, 4a−e, 5a−e, and 6a−e are described. The structures of the regioisomers were elucidated by using extensive NMR studies. The pyrazolylnucleosides 5a−e and 6a−e were screened for anticancer activities on sixty human tumor cell lines. The compound 6e showed good activity against 39 cancer cell lines. In particular, it showed significant inhibition against the lung cancer cell line Hop-92 (GI50 9.3 µM) and breast cancer cell line HS 578T (GI50 3.0 µM).
Databáze:	Directory of Open Access Journals
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