| Autor: |
Luiz Guilherme Fernandes Ramos, Daniela Del Pilar Via Reque Cortes, Luciene Machado dos Reis, Fabio Luiz de Menezes Montenegro, Sérgio Samir Arap, Marília D’Elboux Guimarães Brescia, Melani Ribeiro Custódio, Vanda Jorgetti, Rosilene Motta Elias, Rosa Maria Affonso Moysés |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Brazilian Journal of Nephrology (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2175-8239 |
| DOI: |
10.1590/2175-8239-jbn-2023-0024en |
| Popis: |
Abstract Introduction: Management of secondary hyperparathyroidism (SHPT) is a challenging endeavor with several factors contruibuting to treatment failure. Calcimimetic therapy has revolutionized the management of SHPT, leading to changes in indications and appropriate timing of parathyroidectomy (PTX) around the world. Methods: We compared response rates to clinical vs. surgical approaches to SHPT in patients on maintenance dialysis (CKD 5D) and in kidney transplant patients (Ktx). A retrospective analysis of the one-year follow-up findings was carried out. CKD 5D patients were divided into 3 groups according to treatment strategy: parathyroidectomy, clinical management without cinacalcet (named standard - STD) and with cinacalcet (STD + CIN). Ktx patients were divided into 3 groups: PTX, CIN (cinacalcet use), and observation (OBS). Results: In CKD 5D we found a significant parathormone (PTH) decrease in all groups. Despite all groups had a higher PTH at baseline, we identified a more pronounced reduction in the PTX group. Regarding severe SHPT, the difference among groups was evidently wider: 31%, 14% and 80% of STD, STD + CIN, and PTX groups reached adequate PTH levels, respectively (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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