| Autor: |
Chang Lu, Marjo M. P. C. Donners, Julius B. J. de Baaij, Han Jin, Jeroen J. T. Otten, Marco Manca, Anton Jan van Zonneveld, J. Wouter Jukema, Adriaan Kraaijeveld, Johan Kuiper, Gerard Pasterkamp, Barend Mees, Judith C. Sluimer, Rachel Cavill, Joël M. H. Karel, Pieter Goossens, Erik A. L. Biessen |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2024.1286382 |
| Popis: |
IntroductionThe impact of cardiovascular disease (CVD) risk factors, encompassing various biological determinants and unhealthy lifestyles, on the functional dynamics of circulating monocytes—a pivotal cell type in CVD pathophysiology remains elusive. In this study, we aimed to elucidate the influence of CVD risk factors on monocyte transcriptional responses to an infectious stimulus.MethodsWe conducted a comparative analysis of monocyte gene expression profiles from the CTMM – CIRCULATING CELLS Cohort of coronary artery disease (CAD) patients, at baseline and after lipopolysaccharide (LPS) stimulation. Gene co-expression analysis was used to identify gene modules and their correlations with CVD risk factors, while pivotal transcription factors controlling the hub genes in these modules were identified by regulatory network analyses. The identified gene module was subjected to a drug repurposing screen, utilizing the LINCS L1000 database.ResultsMonocyte responsiveness to LPS showed a highly significant, negative correlation with blood pressure levels (ρ< -0.4; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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