| Autor: |
Bo Gao, Qiang Huang, Yan-Shui Lin, Bo-Yuan Wei, Yun-Shan Guo, Zhen Sun, Long Wang, Jing Fan, Hong-Yang Zhang, Yue-Hu Han, Xiao-Jie Li, Jun Shi, Jian Liu, Liu Yang, Zhuo-Jing Luo |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 9, Iss 6, p e99137 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0099137 |
| Popis: |
Fat infiltration within marrow cavity is one of multitudinous features of estrogen deficiency, which leads to a decline in bone formation functionality. The origin of this fat is unclear, but one possibility is that it is derived from osteoblasts, which transdifferentiate into adipocytes that produce bone marrow fat. We examined the dose-dependent effect of 17β-estradiol on the ability of MC3T3-E1 cells and murine bone marrow-derived mesenchymal stem cell (BMMSC)-derived osteoblasts to undergo osteo-adipogenic transdifferentiation. We found that 17β-estradiol significantly increased alkaline phosphatase activity (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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