Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity

Autor: Thomas Dahlet, Andrea Argüeso Lleida, Hala Al Adhami, Michael Dumas, Ambre Bender, Richard P. Ngondo, Manon Tanguy, Judith Vallet, Ghislain Auclair, Anaïs F. Bardet, Michael Weber
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16919-w
Popis: DNA methyltrasferases play important role during mouse embryo development. Here the authors reveal the consequences of genetic inactivation of Dnmt1, Dnmt3a and Dnmt3b on the methylome and transcriptome of mouse embryos genome-wide.
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