| Autor: |
Sikiru Olatunji Usman, Ibrahim Adekunle Oreagba, Akinwumi Akinyinka Akinyede, Esther Oluwatoyin Agbaje, Moshood Olusola Akinleye, Adaobi Goodness Onwujuobi, Chioma Ken-Owotor, Olatunbosun Adeuja, Tosin Ogunfowokan, Segun Kogbe, Emmanuel Tope Owolabi, Hannah Adeniji, Abdul Wasiu Busari, Olayinka Olayiwola Hassan, Ganiu Abideen, Alani Sulaimon Akanmu |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 144, Iss 3, Pp 95-101 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1016/j.jphs.2020.07.013 |
| Popis: |
Patients living with HIV in malarial endemic regions may experience clinically significant drug interaction between antiretroviral and antimalarial drugs. Effects of nevirapine (NVP), efavirenz (EFV) and lopinavir/ritonavir (LPVr) on lumefantrine (LM) therapeutic concentrations and toxicity were evaluated. In a four-arm parallel study design, the blood samples of 40 participants, treated with artemether/lumefantrine (AL), were analysed. Lumefantrine Cmax was increased by 32% (p = 0.012) and 325% (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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