Metabolic pattern formation in the tumor microenvironment

Autor: Ziwei Dai, Jason W Locasale
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Molecular Systems Biology, Vol 13, Iss 2, Pp 1-2 (2017)
Druh dokumentu: article
ISSN: 1744-4292
DOI: 10.15252/msb.20167518
Popis: Abstract Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within the tumor microenvironment. This spatial organization is linked to gradients derived from Wnt signaling and nutrient availability that mediate a reaction‐diffusion mechanism and is consistent with a Turing‐type model of spatial localization.
Databáze: Directory of Open Access Journals
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