SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
| Autor: | MARCO ANTONIO EDUARDO KOFF, LUKMAN OLALEKAN AJIBOYE, NATÁLIA DIEL LISBOA, ASDRUBAL FALAVIGNA |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Předmět: | |
| Zdroj: | Coluna/Columna, Vol 16, Iss 1, Pp 67-73 |
| Druh dokumentu: | article |
| ISSN: | 2177-014X 1808-1851 |
| DOI: | 10.1590/s1808-1851201716011171639 |
| Popis: | ABSTRACT The objective of the paper is to analyze the frequency and efficacy of experimental studies with antioxidant therapy. A search was conducted in the pubmed.gov database using the keywords "antioxidants" AND "spinal cord injury", from January 2000 to December 2015, resulting in 686 articles. Studies of non-traumatic injuries, non-antioxidant therapies, absence of neurological and functional evaluation, and non-experimental studies were excluded, leaving a total of 43 articles. The most used therapies were melatonin (16.2%), quercetin (9.3%), epigallocatechin and edaravone (6.9%). The most frequent route of administration was intraperitoneal (72.09%). The dose and mode of administration varied greatly, with a single dose being the most commonly used (39.53%). The time elapsed from trauma to treatment was 0-15 minutes (41.8%), 15-60 minutes (30%) and over 60 minutes (10.6%). Histological analysis was performed in 32 studies (74.41%). The BBB scale was the main functional measure applied (55.8%), followed by the inclined plane test (16.2%) and the Tarlov scale (13.9%). Positive outcomes were observed in 37 studies (86.04%). The heterogeneity of antioxidant therapy, with different types, doses, and measurements observed, limits the comparison of efficacy. Standardized protocols are required to make clinical translation possible. |
| Databáze: | Directory of Open Access Journals |
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