Outer retina changes on optical coherence tomography in vitamin A deficiency

Autor: Meghan K. Berkenstock, Charles J. Castoro, Andrew R. Carey
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Retina and Vitreous, Vol 6, Iss 1, Pp 1-5 (2020)
Druh dokumentu: article
ISSN: 2056-9920
DOI: 10.1186/s40942-020-00224-1
Popis: Abstract Background Vitamin A deficiency is rare in the United States and can be missed in patients with malabsorption syndromes without a high dose of suspicion. Ocular complications of hypovitaminosis A include xerosis and nyctalopia, and to a lesser extent reduction in visual acuity and color vision. Outer retinal changes, as seen on spectral domain optic coherence tomography (SD-OCT), in patients with vitamin A deficiency have previously not been documented. Case presentation We present two cases with symptoms of severe nyctalopia who were subsequently diagnosed with severe Vitamin A deficiency and their unique findings on SD-OCT of outer nuclear layer diffuse thinning with irregular appearance of the interdigitating zone and the ellipsoid zone as well as normalization after vitamin A supplementation. Conclusions Outer nuclear layer thinning and disruption of the outer retinal bands on SD-OCT are reversible with correction of vitamin A deficiency. Improvement in visual acuity, color vision, and nyctalopia are possible with early diagnosis and appropriate treatment.
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