Emotional dysregulation and callous unemotional traits as possible predictors of short-term response to methylphenidate monotherapy in drug-naïve youth with ADHD

Autor: Gabriele Masi, Pamela Fantozzi, Pietro Muratori, Giulia Bertolucci, Annalisa Tacchi, Arianna Villafranca, Chiara Pfanner, Samuele Cortese
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Comprehensive Psychiatry, Vol 100, Iss , Pp 152178- (2020)
Druh dokumentu: article
ISSN: 0010-440X
DOI: 10.1016/j.comppsych.2020.152178
Popis: Background: Emotional dysregulation (ED) and callous unemotional (CU) traits can be associated with ADHD in youth, influencing its natural history and outcome, but their effect on medication efficacy is unexplored. We examined whether two measures of baseline ED and CU traits, the Child Behavior Checklist-Dysregulation Profile (CBCL-DP) and the Antisocial Process Screening Device (APSD), respectively, were predictors of change of ADHD-Rating Scale (ADHD-RS) after a 4-week methylphenidate (MPH) monotherapy. Methods: 43 patients (37 males, 8–16 years, mean 9.9 ± 2.7 years) were included. Hierarchical linear regression models were used to explore whether CBCL-DP and APSD might predict ADHD-RS score, controlling for baseline severity. Results: Baseline CBCL-DP predicted higher post-treatment ADHD-RS scores in total and hyperactivity-impulsivity, but not in inattention subscale. Baseline APSD was not significantly related to ADHD-RS scores at the follow-up. Limitations: Small sample size, lack of gender diversity, non-blind design and short period of observation. Conclusion: ED, assessed with that CBCL-DP, might be a negative predictor of change of hyperactive-impulsive symptoms after MPH treatment and should be systematically assessed at baseline.
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