Analysis of cytokine levels, cytological findings, and MP‐DNA level in bronchoalveolar lavage fluid of children with Mycoplasma pneumoniae pneumonia

Autor: Fang Deng, Huiling Cao, Xiaohua Liang, Qubei Li, Yang Yang, Zhihua Zhao, Junjie Tan, Guo Fu, Chang Shu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Immunity, Inflammation and Disease, Vol 11, Iss 5, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2050-4527
DOI: 10.1002/iid3.849
Popis: Abstract Background The present study was conducted to determine the inflammatory response in the lungs of children with Mycoplasma pneumoniae pneumonia (MPP). Methods This study retrospectively analyzed cytokine levels, cytological findings, and M. pneumoniae (MP)‐DNA level in the bronchoalveolar lavage fluid (BALF) of 96 children with MPP. The study utilized Spearman's correlation method to evaluate the contribution of BALF and blood parameters in MPP children. Results (1) A total of 96 MPP children were classified into the Low MP‐DNA MPP group (BALF MP‐DNA ≤ 105 copies/mL) and the High MP‐DNA MPP group (BALF MP‐DNA > 105copies/mL); the Non‐fever MPP group (no fever during the entire course of pneumonia) and the Fever MPP group; the Defervescence MPP group (fever had subsided at the time of bronchoscopy) and the Fervescence MPP group; and the Mild MPP group and the Severe MPP group. (2) The High MP‐DNA MPP, Fever MPP, Fervescence MPP, and Severe MPP groups had higher levels of interleukin (IL)‐6, IL‐10, and tumor necrosis factor‐α (TNF‐α) in their BALF (all p
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