Prognostic indicators in pituitary adenoma surgery: a comprehensive analysis of surgical outcomes and complications

Autor: George Riley, Nicolas Scheyer, Marc Klein, Isabelle Merlot, Bruno Guerci, Elodie Jeanbert, Lea Demarquet
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Endocrinology, Vol 14 (2024)
Druh dokumentu: article
ISSN: 1664-2392
DOI: 10.3389/fendo.2023.1327404
Popis: ObjectiveThe primary aim of this study was to identify predictive factors associated with onset of de-novo clinically significant pituitary insufficiencies following endoscopic endonasal surgery (EES) for pituitary adenomas. The secondary objective explored the predictive factors of surgical successMethodsA retrospective analysis was conducted on 211 patients who underwent EES. Logistic regression models were employed for the primary and secondary objectives. Patients were stratified into specific groups based on surgical indications and prolactin levels for nuanced analysis.ResultsSignificant predictors for de-novo pituitary insufficiencies included male sex (OR 3.3, CI95% 1.3-8.1, p=0.01), immediate postoperative insufficiencies (OR 5.6, CI95% 2.8-11.1, p
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