Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles
| Autor: | Felyx Wong, Aditi Reddy, Yeanuk Rho, Jan Vollert, Paul H. Strutton, Sam W. Hughes |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | PAIN Reports, Vol 8, Iss 3, p e1071 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2471-2531 00000000 |
| DOI: | 10.1097/PR9.0000000000001071 |
| Popis: | Abstract. Introduction:. Topical application of capsaicin can produce an ongoing pain state in healthy participants. However, approximately one-third report no pain response (ie, nonresponders), and the reasons for this are poorly understood. Objectives:. In this study, we investigated temporal summation of pain (TSP) profiles, pain ratings and secondary hyperalgesia responses in responders and nonresponders to 1% topical capsaicin cream. Methods:. Assessments were made at baseline and then during an early (ie, 15 minutes) and late (ie, 45 minutes) time points post-capsaicin in 37 healthy participants. Results:. Participants reporting a visual analogue scale (VAS) rating of >50 were defined as responders (n = 24) and those with |
| Databáze: | Directory of Open Access Journals |
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