Gene expression dysregulation domains are not a specific feature of Down syndrome
| Autor: | Helena Ahlfors, Nneka Anyanwu, Edvinas Pakanavicius, Natalia Dinischiotu, Eva Lana-Elola, Sheona Watson-Scales, Justin Tosh, Frances Wiseman, James Briscoe, Karen Page, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 68801254 |
| DOI: | 10.1038/s41467-019-10129-9 |
| Popis: | Gene expression dysregulation domains (GEDDs) have been reported in Down syndrome (DS) cells, where changes in gene expression are clustered. Here the authors find that, while GEDDs are present in DS cells and in the Dp1Tyb mouse model of DS, GEDDs do not depend on the DS genotype and occur whenever gene expression changes, suggesting they result from the clustering of co-regulated genes as a function of mammalian genome organisation. |
| Databáze: | Directory of Open Access Journals |
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