| Autor: |
Andressa de Souza BERTOLDI, Camila Roginski GUETTER, Gabriel Antonio COLTRO, Larissa Maria VOSGERAU, Laura Maria Viscardi BRIGHENTI, Natália Izycki FAUAT, Fernando Bermudez KUBRUSLY, Camila Aparecida Moraes MARQUES, Luiz Fernando KUBRUSLY |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
ABCD: Arquivos Brasileiros de Cirurgia Digestiva, Vol 33, Iss 3 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0102-6720 |
| DOI: |
10.1590/0102-672020200003e1525 |
| Popis: |
ABSTRACT Background: Portal hypertension (PH) can be measured indirectly through a hepatic vein pressure gradient greater than 5 mmHg. Cirrhosis is the leading cause for PH and can present as complications ascites, hepatic dysfunction, renal dysfunction, and esophagogastric varices, characterizing gastropathy. Aim: To evaluate the use of carvedilol as primary prophylaxis in the development of collateral circulation in rats submitted to the partial portal vein ligament (PPVL) model. Method: This is a combined qualitative and quantitative experimental study in which 32 Wistar rats were divided into four groups (8 animals in each): group I - cirrhosis + carvedilol (PPVL + C); group II - cirrhosis + vehicle (PPVL); group III - control + carvedilol (SO-sham-operated + C); group IV - control + vehicle (SO-sham-operated). After seven days of the surgical procedure (PPVL or sham), carvedilol (10 mg/kg) or vehicle (1 mL normal saline) were administered to the respective groups daily for seven days. Results: The histological analysis showed no hepatic alteration in any group and a decrease in edema and vasodilatation in the PPVL + C group. The laboratory evaluation of liver function did not show a statistically significant change between the groups. Conclusion: Carvedilol was shown to have a positive effect on gastric varices without significant adverse effects. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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