| Autor: |
D. R. Dolgova, T. P. Gening, T. V. Abakumova, S. O. Gening, I. I. Antoneeva, A. B. Pescov, A. Yu. Fedotova |
| Jazyk: |
ruština |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Антибиотики и Химиотерапия, Vol 64, Iss 5-6, Pp 18-21 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0235-2990 |
| DOI: |
10.24411/0235-2990-2019-100026 |
| Popis: |
Determined the primary chemoresistance markers (expression of genes ERCC1, TOP2a and ABCB1) in epithelial cells of ascites 32 primary patients with verified ovarian cancer using RT-PCR. After standard chemotherapy by the AR scheme (cisplatin+doxoru-bicin), the relapse-free survival of patients was assessed by Kaplan-Mayer. Patients with early (up to 6 months) and late (more than 6 months) relapse were isolated. As a result of the conducted studies it was established that early relapse occurred in 67% of the examined patients (the relapse-free period was 88.7+13.3 days). At the same time, in the groups with increased expression, the relapse-free period did not differ significantly, there were early relapses. The use of the Cochrane Q-test has allowed to establish that the reduced levels of ERCC1 and ABCB1, the proportion of survivors is to 72.7% (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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