Autor: |
Ganga B. Vamisetti, Abhishek Saha, Yichao J. Huang, Rajeshwer Vanjari, Guy Mann, Julia Gutbrod, Nabieh Ayoub, Hiroaki Suga, Ashraf Brik |
Jazyk: |
angličtina |
Rok vydání: |
2022 |
Předmět: |
|
Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022) |
Druh dokumentu: |
article |
ISSN: |
2041-1723 |
DOI: |
10.1038/s41467-022-33808-6 |
Popis: |
Finding a selective modulator of Lys63-linked ubiquitin chains has proven very challenging. Here, the authors develop potent macrocyclic peptide binders of Lys63-linked di-ubiquitin chains that interrupt DNA damage repair and lead to apoptotic cell death. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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