MRI and single-cell RNA sequence results reveal the influence of anterior talofibular ligament injury on osteochondral lesions of the talus

Autor:	Jie Xu, Siyi Yang, Ruiqi Fan, Hongbo Wu, Hui Mo
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
Zdroj:	Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-9 (2024)
Druh dokumentu:	article
ISSN:	1749-799X
DOI:	10.1186/s13018-024-04826-5
Popis:	Abstract Anterior talofibular ligament injuries and osteochondral lesions of the talus present unique challenges to orthopedic surgeons. This study aimed to investigate the relevant relationship between them by analyzing the Magnetic resonance imaging (MRI) results of clinical patients and single-cell RNA sequence (scRNA seq) results of healthy talus cartilage to discuss the risk factors. Data from 164 patients from 2018 to 2023 was retrospectively analyzed. The correlation analysis between ATFL injury grade and the Hepple stage of OLT determined by MRI was performed. Publicly available single-cell RNA datasets were collected. Single-cell RNA datasets from five volunteers of healthy talus cartilage were analyzed. ATFL injury grade was relevant with the Hepple stage of OLT (P
Databáze:	Directory of Open Access Journals
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