Association of COL1A1 gene -1997 C>A (rs1107946) polymorphism with bone mineral density in postmenopausal women
| Autor: | E. A. Maylyan |
|---|---|
| Jazyk: | English<br />Russian |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Медицинский вестник Юга России, Vol 8, Iss 2, Pp 23-29 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2219-8075 2618-7876 |
| DOI: | 10.21886/2219-8075-2017-8-2-23-29 |
| Popis: | Objective: to study bone mineral density indexes in zone of L1-L4 lumbar vertebrae and left and right femur proximal departments including left and right femoral necks in postmenopausal women according to genotypes of -1997 C>A polymorphism of COL1A1 gene. Materials and methods: 483 Caucasian women from eastern and central regions of Ukraine were examined. All women were postmenopausal. Osteodensitometry was carried out by dual-energy X-ray absorptiometry method. Detection of a gene COL1A1 -1997 C>A polymorphism was carried out by the real-time PCR method. Results: it was established that the low bone mineral density indicators in zone of left femoral neck were associated with AA genotype (Р=0,040), and in zone of right femoral neck and proximal department – with AA and CA genotypes (Р=0,008-P=0,035). Association of polymorphic variations of COL1A1 gene (-1997 C>A) with mineral density of L1-L4 lumbar vertebrae was not established. Conclusion: the obtained data can be used for detection of predisposition to postmenopausal osteoporosis development and increase of treatment-and-prophylactic actions effectiveness. |
| Databáze: | Directory of Open Access Journals |
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