| Autor: |
Ingrid Cristiane Pereira Gomes, Lucas Sousa Magalhães, Lays Gisele Santos Bomfim, Priscila Lima dos Santos, Roberto Jerônimo dos Santos Silva, Maria Carollyne Passos Cruz, Lindemberg Costa deAlbuquerque, Victoria Haydée Deusdedith Neves, Paula Gabriella Pereira Rosa deOliveira, Alessandro Freire Carvalho, Lucas Oliveira Silva, Matheus Todt Aragão, Tatiana Rodrigues Moura, Rosana Cipolotti |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
eJHaem, Vol 4, Iss 3, Pp 705-709 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2688-6146 |
| DOI: |
10.1002/jha2.712 |
| Popis: |
Abstract Although sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross‐sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher levels of lactato dehydrogenase, IL‐1β, IL‐6, IL‐10, and tumor necrosis factor alpha than the others, while the SCT group had similar levels to control group. In addition, SCA group had lower IL‐8/IL‐10 and soluble triggering receptor expressed on myeloid cells‐1/IL‐10 ratios. These findings indicate that individuals with SCT do not have a chronic inflammatory profile and reinforce that cytokines are involved in the maintenance of the inflammatory state in SCA. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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