Clinical and genetic aspects of differential diagnostics of hereditary non-polyposis colorectal cancer

Autor:	A. V. Semyanikhina, A. O. Rasulov, L. N. Lyubchenko
Jazyk:	ruština
Rok vydání:	2019
Předmět:	lynch syndrome lynch-like syndrome colorectal cancer hereditary non-polyposis colorectal cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Успехи молекулярной онкологии, Vol 6, Iss 2, Pp 21-27 (2019)
Druh dokumentu:	article
ISSN:	2313-805X 2413-3787
DOI:	10.17650/2313-805X-2019-6-2-21-27
Popis:	Lynch syndrome was synonymous with hereditary non-polyposis colorectal cancer for a long time, however, mapping of the DNA mismatch repair (MMR) genes has led to distinguish Lynch syndrome as an independent syndromic unit from a number of Lynch-like syndromes that phenotypically mimic with the most frequent hereditary variant of colon cancer but genetically representing quite a heterogeneous group. This article presents up to date clinical and genetic characteristics of Lynch syndrome and Lynch-like conditions.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5896f863d021448eb3888dda0ff12093 Zobrazit plný text záznamu View record in DOAJ