Lung cancer risk prediction models based on pulmonary nodules: A systematic review

Autor: Zheng Wu, Fei Wang, Wei Cao, Chao Qin, Xuesi Dong, Zhuoyu Yang, Yadi Zheng, Zilin Luo, Liang Zhao, Yiwen Yu, Yongjie Xu, Jiang Li, Wei Tang, Sipeng Shen, Ning Wu, Fengwei Tan, Ni Li, Jie He
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Thoracic Cancer, Vol 13, Iss 5, Pp 664-677 (2022)
Druh dokumentu: article
ISSN: 1759-7714
1759-7706
DOI: 10.1111/1759-7714.14333
Popis: Abstract Background Screening with low‐dose computed tomography (LDCT) is an efficient way to detect lung cancer at an earlier stage, but has a high false‐positive rate. Several pulmonary nodules risk prediction models were developed to solve the problem. This systematic review aimed to compare the quality and accuracy of these models. Methods The keywords “lung cancer,” “lung neoplasms,” “lung tumor,” “risk,” “lung carcinoma” “risk,” “predict,” “assessment,” and “nodule” were used to identify relevant articles published before February 2021. All studies with multivariate risk models developed and validated on human LDCT data were included. Informal publications or studies with incomplete procedures were excluded. Information was extracted from each publication and assessed. Results A total of 41 articles and 43 models were included. External validation was performed for 23.2% (10/43) models. Deep learning algorithms were applied in 62.8% (27/43) models; 60.0% (15/25) deep learning based researches compared their algorithms with traditional methods, and received better discrimination. Models based on Asian and Chinese populations were usually built on single‐center or small sample retrospective studies, and the majority of the Asian models (12/15, 80.0%) were not validated using external datasets. Conclusion The existing models showed good discrimination for identifying high‐risk pulmonary nodules, but lacked external validation. Deep learning algorithms are increasingly being used with good performance. More researches are required to improve the quality of deep learning models, particularly for the Asian population.
Databáze: Directory of Open Access Journals
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