Iron oxide nanoparticles with supramolecular ureidopyrimidinone coating

Autor: Turrina Chiara, Dankers Patricia Y. W., Berensmeier Sonja, Schwaminger Sebastian
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Current Directions in Biomedical Engineering, Vol 8, Iss 2, Pp 13-16 (2022)
Druh dokumentu: article
ISSN: 2364-5504
DOI: 10.1515/cdbme-2022-1004
Popis: Superparamagnetic iron oxide nanoparticles are a promising material in nanomedicine, especially for generating magnetically controlled drug delivery systems. We developed an innovative ureidopyrimidinone (UPy) coating based on supramolecular hydrogen bonding units. The synthesized nanoparticles possess a positively charged surface with a hydrodynamic diameter of 177 nm at pH 7 and magnetization of 31 emu g-1. The system has the potential to be modified by drugs or bioactive molecules altered with UPy units.
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