| Autor: |
Rania A. Gad, Eman S. Abdel-Reheim, Hossam Ebaid, Ibrahim M. Alhazza, Abdelaziz S.A. Abuelsaad |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of King Saud University: Science, Vol 34, Iss 3, Pp 101886- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1018-3647 |
| DOI: |
10.1016/j.jksus.2022.101886 |
| Popis: |
Virulent epileptogenic insult is still one of the most life-threatening deficits during the clinical consequences and neurological emergencies of epilepsy. Thus, this study is designed to determine the changes in the expression of neurotransmitters, imbalance in blood electrolytes; oxidative stress, levels of pro-/anti-inflammatory cytokines, after treatment with pasipay (Passiflora incarnata). The effect of oral administration of 200 mg/kg body weight of P. incarnata on pilocarpine-induced seizures was assessed. The correlation between seizure activity and levels of proinflammatory cytokines; anti-inflammatory cytokines; oxidative stress biomarkers, monoamines, neurotransmitters; electrolytes and Th1/Th2 activities was quantified. The present study revealed a highly significant amelioration in amino acids, neurotransmitters, blood electrolytes, antioxidants and inflammatory cytokines in epileptic-treated rats with pasipay (P. incarnata). In conclusion, the present study supports further attempts to abrogate the neural dysfunction via antioxidant and anti-inflammatory cascade activities using P. incarnata. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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