| Autor: |
Priya Jegatheesan, Matthew Nudelman, Dongli Song, Angela Huang, Maria Cortes, Alan Wu, Mary Prahl, Stephanie L Gaw, Sudha Rani Narasimhan, Daljeet S Rai, Claudia V Flores, Christine Y Lin, Unurzul Jigmeddagva, Lakshmi Warrier, Justine Levan, Catherine B T Nguyen, Perri Callaway, Lila Farrington, Gonzalo R Acevedo, Veronica J Gonzalez, Anna Vaaben, Elda Atmosfera, Constance Marleau, Christina Anderson, Sonya Misra, Monica Stemmle, Jennifer McAuley, Nicole Metz, Rupalee Patel, Susan Abraham |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
BMJ Open, Vol 11, Iss 7 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2021-053036 |
| Popis: |
Objective To investigate maternal immunoglobulins’ (IgM, IgG) response to SARS-CoV-2 infection during pregnancy and IgG transplacental transfer, to characterise neonatal antibody response to SARS-CoV-2 infection, and to longitudinally follow actively and passively acquired antibodies in infants.Design A prospective observational study.Setting Public healthcare system in Santa Clara County (California, USA).Participants Women with symptomatic or asymptomatic SARS-CoV-2 infection during pregnancy and their infants were enrolled between 15 April 2020 and 31 March 2021.Outcomes SARS-CoV-2 serology analyses in the cord and maternal blood at delivery and longitudinally in infant blood between birth and 28 weeks of life.Results Of 145 mothers who tested positive for SARS-CoV-2 during pregnancy, 86 had symptomatic infections: 78 with mild-moderate symptoms, and 8 with severe-critical symptoms. The seropositivity rates of the mothers at delivery was 65% (95% CI 0.56% to 0.73%) and the cord blood was 58% (95% CI 0.49% to 0.66%). IgG levels significantly correlated between the maternal and cord blood (Rs=0.93, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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