| Autor: |
Sajjad Jabermoradi, Parsa Paridari, Hamzah Adel Ramawad, Pantea Gharin, Shayan Roshdi, Amirmohammad Toloui, Mahmoud Yousefifard |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Archives of Academic Emergency Medicine, Vol 13, Iss 1 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2645-4904 |
| DOI: |
10.22037/aaem.v13i1.2261 |
| Popis: |
Introduction: Exosomes function as cell signaling carriers and have drawn much attention to the cell-free treatments of regenerative medicine. This meta-analysis aimed to investigate the efficacy of mesenchymal stem cell-derived (MSC-derived) exosomes in animal models of spinal cord injuries (SCI). Method: A comprehensive search was conducted in Medline, Embase, Scopus, and Web of Science to attain related articles published by January 31, 2023. The eligible keywords were correlated with the spinal cord injury and MSC-derived exosomes. The evaluated outcomes were locomotion, cavity size, cell apoptosis, inflammation, neuro-regeneration, and microglia activation. A standardized mean difference was calculated for each sample and a pooled effect size was reported. Results: 65 papers fully met the inclusion criteria. Treatment with MSC-derived exosomes ultimately improved locomotion and shrunk cavity size (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
