| Autor: |
Farrah B. Khan, MD, Pamela C. Gibson, MD, Scott Anderson, MD, Sarah Wagner, BS, Bernard F. Cole, PhD, Peter Kaufman, MD, C. Matthew Kinsey, MD, MPH |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
JTO Clinical and Research Reports, Vol 5, Iss 3, Pp 100634- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3643 |
| DOI: |
10.1016/j.jtocrr.2024.100634 |
| Popis: |
Neoadjuvant intratumoral cisplatin has the potential to generate substantial cytotoxicity and immune priming within the tumor environment, while minimizing systemic, off-target, adverse events. We initiated a phase 1A, 3+3 dose-ranging study of neoadjuvant, intratumoral cisplatin, delivered through endobronchial ultrasound bronchoscopy, in the same procedure as the initial diagnosis. There were no dose-limiting toxicity identified at the 20mg level |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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