Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome
| Autor: | Cara Lunn Shirai, Brian S. White, Manorama Tripathi, Roberto Tapia, James N. Ley, Matthew Ndonwi, Sanghyun Kim, Jin Shao, Alexa Carver, Borja Saez, Robert S. Fulton, Catrina Fronick, Michelle O’Laughlin, Chandraiah Lagisetti, Thomas R. Webb, Timothy A. Graubert, Matthew J. Walter |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 58561889 |
| DOI: | 10.1038/ncomms14060 |
| Popis: | Spliceosome mutations occur in approximately 50% of patients with myelodysplastic syndromes. Here, the authors show that tumour cells harbouring theS34F mutation in the U2AFspliceosome gene is sensitive to compounds that further perturb the spliceosome. |
| Databáze: | Directory of Open Access Journals |
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