| Autor: |
Mohamed Ali Smach, Hayet Edziri, Bassem Charfeddine, Leila Ben Othman, Turkia Lammouchi, Afef Ltaief, Souhir Nafati, Hedi Dridi, Soufien Bennamou, Khalifa Limem |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Dementia and Geriatric Cognitive Disorders Extra, Vol 1, Iss 1, Pp 249-257 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1664-5464 |
| DOI: |
10.1159/000329910 |
| Popis: |
Background: Apolipoprotein A1 (apoA1) is the major apolipoprotein constituent of the high-density lipoprotein (HDL) and is involved in reverse cholesterol transport. Variation in the apoA1 gene might influence the function of the protein and, thus, brain cholesterol metabolism, leading to an increased risk for Alzheimer’s disease (AD). Aim: In the current report, we investigated the role of the functional apoA1 polymorphism (–75 G/A) as a genetic risk factor for AD in a Tunisian population. Methods: 173 AD patients and 150 healthy controls were studied. Results: No association was found between this genetic variation in apoA1 gene and the risk of AD. The presence of the (–75 G/A) A allele appeared, however, to be associated with lower levels of cerebrospinal fluid Aβ42 and HDL cholesterol levels in sera. Conclusion: Our data support the observation that apoA1 polymorphism influences cholesterol metabolism and Aβ42 deposition in the brain. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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