| Autor: |
Richard A Furie, Betty Diamond, Bruce Volpe, Ying Jin, Andrew Shih, Arnon Arazi, Erik W Anderson, Julien Roeser, Sara Goodwin |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Lupus Science and Medicine, Vol 9, Iss 1 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2053-8790 |
| DOI: |
10.1136/lupus-2022-000808 |
| Popis: |
Objective Quinolinic acid (QA), a kynurenine (KYN)/tryptophan (TRP) pathway metabolite, is an N-methyl-D-aspartate receptor agonist that can produce excitotoxic neuron damage. Type I and II interferons (IFNs) stimulate the KYN/TRP pathway, producing elevated QA/kynurenic acid (KA), a potential neurotoxic imbalance that may contribute to SLE-mediated cognitive dysfunction. We determined whether peripheral blood interferon-stimulated gene (ISG) expression associates with elevated serum KYN:TRP and QA:KA ratios in SLE.Methods ISG expression (whole-blood RNA sequencing) and serum metabolite ratios (high-performance liquid chromatography) were measured in 72 subjects with SLE and 73 healthy controls (HCs). ISG were identified from published gene sets and individual IFN scores were derived to analyse associations with metabolite ratios, clinical parameters and neuropsychological assessments. SLE analyses were grouped by level of ISG expression (‘IFN high’, ‘IFN low’ and ‘IFN similar to HC’) and level of monocyte-associated gene expression (using CIBERSORTx).Results Serum KYN:TRP and QA:KA ratios were higher in SLE than in HC (p |
| Databáze: |
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