Monomethyl Suberate Screening for Antifungal Activity, Molecular Docking and Drug-Like Properties
| Autor: | Lyudmyla Antypenko, Fatuma A. Hassan, Zhanar Sadykova, Leif-Alexander Garbe, Karl G. Steffens |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Acta Chimica Slovenica, Vol 65, Iss 4, Pp 836-841 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1318-0207 1580-3155 |
| DOI: | 10.17344/acsi.2018.4440 |
| Popis: | Antifungal activity of suberic acid monomethyl ester (monomethyl suberate) was investigated in a growth inhibition assay comprising of 11 different fungi and 3 Phytophthora oomycetes strains relevant in agriculture. In comparison to standard antifungal hymexazol, monomethyl suberate showed moderate antifungal effects at a concentration range of 100 – 300 µg/mL. Alternaria alternata, Fusarium equiseti, Fusarium fujikuroi and Phytophtora infestans GL-1 were the most sensitive fungi showing inhibition rates up to 100 %. Physico-chemical descriptors of monomethyl suberate revealed its low toxicity profile. Molecular docking analysis comprising several known antifungal targets points to the N-myristoyltransferase as the most probable site of interaction. |
| Databáze: | Directory of Open Access Journals |
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