Role of Microbiota in Aetiopathogenesis of Colorectal Cancer

Autor:	Arpita Suri, Sanjiv Kumar Bansal, Prajwal Ammalli, Busi Karunanand
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	butyrate dysbiosis gut microbiota microbiome Medicine
Zdroj:	Journal of Clinical and Diagnostic Research, Vol 13, Iss 9, Pp BE01-BE05 (2020)
Druh dokumentu:	article
ISSN:	2249-782X 0973-709X
DOI:	10.7860/JCDR/2019/42445.13169
Popis:	Colorectal Cancer (CRC) accounts for sizeable disease burden globally. The symbiotic association between gut inhabitants and the digestive tract contributes to gut homeostasis. Studies suggest that altered microbiota composition or dysbiosis can contribute to colorectal carcinogenesis. This review outlines the complex interplay between the microbiome, diet and CRC with a special emphasis on microbial metabolites, gut barrier function, specific bacterial species which influence the micro environment by various mechanisms like oxidative stress, DNA damage, immune modulation and inflammation. This would help in establishing novel diagnostic, prognostic markers and newer therapeutics for CRC.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5840806ff67d4137802996e4aa1f958f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF