Serum thymidine kinase 1 protein concentrations and presence of its autoantibody as biomarkers for screening dogs with malignant tumors

Autor: Yoonhee Kim, Jeongjoo Park, Byunggak Kim, Kyung‐Rok Yu, Hong Sook Kim, Yein Oh, Kyoungwon Seo, Minok Ryu, Chul Park, Dongha Bhang, Ulsoo Choi, Hwayoung Youn
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 38, Iss 1, Pp 300-307 (2024)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16946
Popis: Abstract Background An accurate and easily accessible method for diagnosing malignancies in local veterinary clinics has not yet been established. Objectives To investigate the usefulness of serum thymidine kinase 1 (TK1) protein and its autoantibody as tumor biomarkers in dogs. Animals Serum samples from 1702 dogs were collected from local animal hospitals and referral animal medical centers in South Korea. Methods TK1 protein OD value and TK1 autoantibody ratio (TK1 autoantibody OD/total IgG OD) in serum samples of dogs classified into healthy controls, group with nontumor disease, group with benign and group with malignant tumors were measured using lateral flow immunochromatographic assay methods. Results TK1 autoantibody levels were significantly higher in malignant tumor group (median 0.71) than in healthy controls (median 0.34), group with nontumor disease (median 0.34), and group with benign tumor (median 0.32, Welch t test, P
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