Effects of acute stress on gene expression of splenic catecholamine biosynthetic enzymes in chronically stressed rats
| Autor: | Gavrilović Ljubica, Stojiljković Vesna, Kasapović Jelena, Pejić Snežana, Todorović Ana, Pajović Snežana B., Dronjak Slađana |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Archives of Biological Sciences, Vol 65, Iss 1, Pp 183-189 (2013) |
| Druh dokumentu: | article |
| ISSN: | 0354-4664 1821-4339 |
| DOI: | 10.2298/ABS1301183G |
| Popis: | The aim of this study was to examine how acute immobilization stress affects the concentrations of catecholamines in the plasma and the expression of the splenic catecholamine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine-Я-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) in chronically socially isolated rats. We found that acute immobilization increases the plasma catecholamine levels and splenic PNMT protein levels in chronically socially isolated rats. These results show that acute stress of chronically stressed animals activates the sympatho-adrenomedullary system and increases synthesis of splenic PNMT by 37%, both of which can modulate the immune function. [Projekat Ministarstva nauke Republike Srbije, br. III 41027, br. III 41022 and br. ON 173044] |
| Databáze: | Directory of Open Access Journals |
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