Research of T-SOD and MDA in rabbit lens at the early period after vitrectomy combined with nonexpansile perfluoropropane gas

Autor: Yan-Fang Yang, Song-Bo Jia, Luo-Sheng Tang
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Guoji Yanke Zazhi, Vol 15, Iss 11, Pp 1873-1876 (2015)
Druh dokumentu: article
ISSN: 1672-5123
DOI: 10.3980/j.issn.1672-5123.2015.11.09
Popis: AIM:To study the relationship between oxidative damage and the early pathological changes in rabbit lens after vitrectomy combined with nonexpansile perfluoropropane gas, by detecting T-SOD activity and MDA content at different stages after the operation. METHODS:Fourty five healthy new zealand rabbits were divided randomly to three groups:normal group, control group and experimental group. The control group was just performed vitrectomy with BSS; the experimental group was performed vitrectomy combined with nonexpansile perfluoropropane gas. The lens were made into tissue homogenates to detect T-SOD activity and MDA content by using spectrophotometry on the 1st,3th,8th,35th and 45th day after the operation. RESULTS:T-SOD activity: that in normal group was the hightest, that in experimental group was the lowest, and there was significant difference(PPCONCLUSION:Oxidative damage mechanism may be involved in the early damge of rabbit lens after vitrectomy combined with nonexpansile perfluoropropane gas.
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