Homicide with intramuscular cyanide injection: a case report

Autor: Natasha Tobarran, Emily K. Kershner, Kirk L. Cumpston, S. Rutherfoord Rose, Brandon K. Wills
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Toxicology Communications, Vol 6, Iss 1, Pp 20-22 (2022)
Druh dokumentu: article
ISSN: 24734306
2473-4306
DOI: 10.1080/24734306.2021.2015550
Popis: AbstractCyanide poisoning most commonly occurs from smoke inhalation, less commonly by oral ingestion for suicide or homicide. There are rare cases of intravenous or subcutaneous parenteral cyanide. We report a fatal case of intramuscular cyanide used as a homicidal agent. A 35-year-old female was assaulted and injected with an unknown substance in her left buttock using a syringe. She was unresponsive at ED arrival and underwent immediate endotracheal intubation. After near normal vital signs at arrival (BP 130/83 mmHg, HR 102 bpm), she rapidly became hypotensive and bradycardic with worsening acidosis (pH 6.95, lactate 7.7 mmol/L). Despite vasopressors, hydroxocobalamin, and sodium thiosulfate, she succumbed. Plasma cyanide concentrations from blood drawn 1 and 4 h post exposure were both in the lethal range (3.4 and 4.1 mg/L, respectively). Our case demonstrates that intramuscular injection can result in fatal cyanide poisoning, resulting in rapid absorption, severe toxicity, and death.
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