Quality of life of patients with metastatic pancreatic adenocarcinoma initiating first-line chemotherapy in routine practice

Autor: Berta Laquente, Teresa Macarulla, Cristina Bugés, Marta Martín, Carlos García, Carles Pericay, Sandra Merino, Laura Visa, Teresa Martín, Manuela Pedraza, Beatriz Carnero, Raquel Guardeño, Helena Verdaguer, Alejandro Mut, David Vilanova, Adelaida García
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Palliative Care, Vol 19, Iss 1, Pp 1-11 (2020)
Druh dokumentu: article
ISSN: 1472-684X
DOI: 10.1186/s12904-020-00610-4
Popis: Abstract Background Despite advances in surgery, radiotherapy, and chemotherapy, pancreatic adenocarcinoma often progresses rapidly and causes death. The physical decline of these patients is expected to impact their quality of life (QoL). Therefore, in addition to objective measures of effectiveness, the evaluation of health-related QoL should be considered a matter of major concern when assessing therapy outcomes. Methods Observational, prospective, multicenter study including patients with metastatic pancreatic adenocarcinoma who started first-line chemotherapy in 12 Spanish centers. Treatment and clinical characteristics were recorded at baseline. Patients’ health-related quality of life, ECOG, and Karnofsky index were measured at baseline, at Days 15 and 30, and every four weeks up to 6 months of chemotherapy. Health-related quality of life was measured using the EORTC-QLQ-C30 and EQ-5D questionnaires. Other endpoints included overall survival and progression-free survival. Results The study sample included 116 patients (median age of 65 years). Mean (SD) scores for the QLQ-C30 global health status scale showed a significant increasing trend throughout the treatment (p = 0.005). Patients with either a Karnofsky index of 70–80 or ECOG 2 showed greater improvement in the QLQ-C30 global health status score than the corresponding groups with better performance status (p ≤ 0.010). Pain, appetite, sleep disturbance, nausea, and constipation significantly improved throughout the treatment (p
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