Trends in participant race and sex reporting in lung cancer phase III clinical trials

Autor: Faaiq N. Aslam, Rami Manochakian, Yanyan Lou, Gerardo Colon‐Otero, Taimur Sher
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Cancer Reports, Vol 6, Iss S1, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2573-8348
DOI: 10.1002/cnr2.1856
Popis: Abstract Background Clinical trials are an essential part of advancing care for cancer patients. Historically, however, racial minorities and females have been underrepresented in these trials. Efforts like the National Institute of Health Revitalization Act attempted to mitigate these disparities, but despite these efforts, they continue to exist. These disparities can subsequently lead to minorities and females receiving suboptimal care. Aims The purpose of our study was to understand the changing trends in reporting of participant race and sex as a demographic variable in phase III lung cancer clinical trials published over the last 35 years given these consequences of poor representation. Methods and results A total of 426 articles reporting the results of phase III lung cancer clinical trials published from 1984 to 2019 were identified in PubMed. From these articles, data on participant sex and race were collected from the demographic tables to construct the database for this study. This database was subsequently used to determine the rate of reporting of demographic factors like race and sex and the participation trends over the time of minority and female participation in lung cancer phase III clinical trials. The SciPy Stats package for Python was used to calculate descriptive statistics, 95% confidence intervals, two sample t‐test, one‐way analysis of variance test, and Pearson's correlation coefficients. The Matplotlib package for Python was used for figure generation. Only 137 (32.2%) of the 426 studies analyzed reported the race of participants. Among those studies, we found that the mean participation rate of White participants was significantly higher (82.65%; p
Databáze: Directory of Open Access Journals
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