Tumor Marker Decline in Predicting Treatment Outcome among Poor-Risk Testicular Germ Cell Tumors—A Tertiary Cancer Center Data
| Autor: | Lakshmi Haridas K., Francis V. James, Aswin Kumar, John Joseph, Jagathnath Krishna KM |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | South Asian Journal of Cancer, Vol 11, Iss 03, Pp 218-222 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2278-330X 2278-4306 |
| DOI: | 10.1055/s-0042-1743423 |
| Popis: | Abstract Lakshmi Haridas K. Introduction Testicular germ cell tumors are rare in India. Despite the advances in chemotherapy, poor-risk testicular nonseminomatous germ cell tumors (NSGCT) remain as a clinical challenge. Various prognostic factors have been described in this rare disease. The Indian data in this regard is scarce. Our study is the first attempt to assess the tumor marker decline with respect to treatment outcome in poor-risk NSGCT in Indian patients. Materials and Methods This retrospective study was done among newly diagnosed poor-risk NSGCT, treated at genitourinary clinic, at our tertiary cancer center during the period 2017 to 2019. The prognostic significance of tumor marker decline in them was correlated with 2-year progression-free survival (PFS) and 2-year overall survival (OS). Statistical Methods The association between two variables were assessed using chi-squared/Fischer's exact test. The PFS and OS were estimated using Kaplan–Meier method and the significance difference between survival curves was tested using log rank test. The risk for survival was estimated using cox regression analysis. A p-value of |
| Databáze: | Directory of Open Access Journals |
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